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Year : 2014  |  Volume : 1  |  Issue : 3  |  Page : 123-131

Immunohistochemical evaluation: The effects of propolis on osseointegration of dental implants in rabbit's tibia

1 Department of Oral Histology and Biology, College of Dentistry, University of Kufa, Kufa, Najaf, Iraq
2 Department of Oral Histology and Biology, College of Dentistry, Baghdad University, Baghdad, Iraq
3 Department of OMF Surgery, College of Dentistry, University of Kufa, Kufa Najaf, Iraq

Correspondence Address:
Abbas Taher
Department of OMF Surgery, College of Dentistry, University of Kufa, Kufa Najaf
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2348-2915.146490

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Background: Dental implant is an artificial tooth root-fixed into the jaws to hold a replacement tooth or bridge. Functional surface modifications by organic material such as propolis coating seem to enhance early peri-implant bone formation, enhancing the initial cell attachment. The aim of the study was to study the expression of osteocalcin (OC) and type I collagen (COLL1) as bone formation markers in propolis-coated and -uncoated implant in interval periods (1, 2, 4, and 6 weeks). Materials and Methods: Commercially pure titanium (cpTi) implants, coated with propolis protein, were placed in the tibias of 40 New Zealand white rabbits, histological and immunohistochemical tests for detection of expression of OC and COLL1were performed on all the implants of both control and experimental groups for (1, 2, 4, and 6 weeks) healing intervals. Results: Histological finding for coated titanium implant with propolis illustrated an early bone formation, mineralization, and maturation in comparison to control. Immunohistochemical finding showed that positive reaction for OC and COLL1 was expressed by osteoblast cells at implants coated with propolis, indicating that bone formation and maturation was accelerated by adding biological materials as a modification modality of implant surface. Conclusion: The present study concludes that coating of implants with propolis showed increment in osseointegration in short interval period.

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