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Year : 2020  |  Volume : 7  |  Issue : 3  |  Page : 154-158

Relationship between Helicobacter pylori infection and recurrent aphthous stomatitis

Department of Stomatology, Oral Medicine Unit, Faculty of Dentistry, University of Granada, Granada, Spain

Correspondence Address:
Alberto Rodriguez-Archilla
Department of Stomatology, Oral Medicine Unit, Faculty of Dentistry, Colegio Maximo, S/N. Campus de Cartuja, 18071-Granada
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdrr.jdrr_29_20

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Background: Recurrent aphthous stomatitis (RAS) is a very common ulcerative disease that affects about 20% of the population. Helicobacter pylori infection could be involved in the RAS pathogenesis by inducing an oral cytotoxic immunological response to these bacterial antigens. Objective: The objective of this study is to assess the possible relationship of H. pylori infection with RAS. Methods: A search for articles on H. pylori and RAS was performed in the following electronic databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Spanish Medical Index (IME). Ninety-eight articles (29 in PubMed, 69 in WoS, and none in IME) were found between 1997 and 2018, 28 of them duplicates. From 26 articles with full-text availability, three studies with a score below 6 points on the Newcastle–Ottawa scale were excluded. After applying these criteria, 23 studies were included in this review. Statistical Analysis: For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios using Mantel-Haenszel method with 95% confidence intervals. The Pearson's Chi-square test was also used when necessary. Results: RAS patients were 2.16 times more likely to be infected by H. pylori than controls with a very significant statistical relationship (P < 0.01). 42.0% of RAS patients and 33.8% of controls were infected with H. pylori with a statistically significant association (P = 0.001). Nearly 45.9% of patients infected with H. pylori were located in Asia, 34.7% in the Americas, and 33.0% in Europe, with statistically significant differences (P < 0.01). Conclusions: There is a greater detection of H. pylori in RAS patients than in controls without the disease.

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