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ORIGINAL ARTICLE
Year : 2022  |  Volume : 9  |  Issue : 1  |  Page : 73-77

Efficacy of 0.1% topical tacrolimus in the management of symptomatic geographic tongue: A placebo-controlled study


1 Department of Oral Medicine and Radiology, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India
2 Department of Public Health Dentistry, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India
3 Department of Public Health Dentistry, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India
4 Department of Dental Surgery, Ranchi Institute of Neuro-Psychiatry and Allied Sciences, Ranchi, Jharkhand, India

Correspondence Address:
Rahul Srivastava
Department of Oral Medicine and Radiology, Rama Dental College, Hospital and Research Centre, Kanpur, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdrr.jdrr_127_20

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Background: Geographic tongue is characterized by erythematous patches with whitish margins across the surface of the tongue, with periods of exacerbation and remission that confer the typical migratory aspect of this entity. There is no definite treatment for geographic tongue as yet. The present study aims to evaluate the response of treatment with topical tacrolimus ointment 0.1% w/w (Protopic®) in geographic tongue. Materials and Methods: This was a prospective study involving a total of 14 patients who were randomly divided into two groups, namely Group A and Group B, with 7 patients in each group. Patients were requested to apply 0.1% topical tacrolimus ointment (Protopic®) in an oral base on their lesions and an identical placebo. At each visit, the burning sensation was tested through the Visual Analog Scale and the treatment responses were tested through Tel Aviv-San Francisco Scale. Data were assessed using IBM Statistical Package for Social Sciences (SPSS) Statistics version 21. Results: Patients in Group A (0.1% topical tacrolimus) depicted lower scores of burning sensation after the treatment as compared to Group B (placebo). The overall treatment response was significantly better in Group A than Group B. Conclusion: The results of the present study suggest that topical application of 0.1% tacrolimus is beneficial in the management of symptomatic geographic tongue.


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